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Original Research Article | OPEN ACCESS

Effect of Yushen zhuyun decoction on rats with diminished ovarian reserve induced by tripterygium glycosides

Yuli Jin1, Ying Zhang2, Lishuang Hao3, Li Tan4, Mengfei Zhuang4, Tingting Zhang4

1Department of Traditional Chinese Medicine; 2Department of Endocrinology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080; 3Department of Gynecology, Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200082; 4Department of Gynecology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.

For correspondence:-  Tingting Zhang   Email: ttzhangyy@sina.com   Tel:+862165161782

Received: 12 August 2016        Accepted: 9 July 2017        Published: 31 August 2017

Citation: Jin Y, Zhang Y, Hao L, Tan L, Zhuang M, Zhang T. Effect of Yushen zhuyun decoction on rats with diminished ovarian reserve induced by tripterygium glycosides. Trop J Pharm Res 2017; 16(8):1917-1923 doi: 10.4314/tjpr.v16i8.23

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of Yushen zhuyun decoction (YSZYF) on rats with diminished ovarian reserve (DOR).
Methods: High-performance liquid chromatography (HPLC) was used to determine the major phytochemical constituents of YSZYF. Rats with DOR (DOR rats) were prepared by administration of tripterygium glycosides (TWP) orally (50 mg/kg) for 15 days. Thereafter, DOR rats were treated orally with YSZYF (300, 600 and 900 mg/kg). After 15 days’ treatment, ovary index was calculated and blood was obtained to determine serum levels of follicle-stimulating hormone (FSH), estradiol (E2), progesterone (P), testosterone (T), inhibin (INH) and anti-mullerian hormone (AMH) by radioimmunoassay and enzyme-linked immunosorbent assay (ELISA). In addition, the ovary was subjected to histopathological examinations.
Results: Phytochemical investigation indicated that the major constituents of YSZYF are acteoside, loganin, lcariin and echinacoside. Compared to the control rats, YSZYF treatment enhanced the ovary index of DOR rat (p < 0.05); furthermore, YSZYF treatment also enhanced the number of follicles and corpus luteum, as well as alleviated inflammatory reaction in ovary tissues. Additionally, the serum levels of FSH and T were elevated by treatment of YSZYF (p < 0.01), whereas E2, INHB and AMH concentrations decreased (p < 0.01), compared to control rats.
Conclusion: The findings indicate that YSZYF improves ovarian reserve of DOR rats, and thus has a potential for treating infertility.
 

Keywords: Yushen zhuyun decoction, Diminished ovarian reserve, Infertility, Acteoside, Loganin, Lcariin, Echinacoside

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Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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